Archives of Head and Neck Surgery
Archives of Head and Neck Surgery
Original Article Larynx, hypopharynx and tracheal diseases and tumors

Prognostic significance of perineural invasion in laryngeal cancer

Pedro Banho da Rosa, Vítor Martinez de Carvalho, Angelo Sementilli, Leandro Luongo de Matos, Rogério Aparecido Dedivitis

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Introduction: Perineural invasion (PNI) may be an independent risk factor for lymph node metastasis in laryngeal cancer, impacting on decreased survival, increased rates of locoregional recurrence, and shortening the period for recurrence. Objective: To evaluate the prognostic significance of PNI in laryngeal cancer. Materials and Methods: This is a retrospective study, with review of anatomopathological material of patients with laryngeal cancer surgically treated from March 2009 to May 2016. The presence of PNI is related to the oncological results. Results: Of the 69 patients studied, four presented PNI in the review of the slides, one of which presented local recurrence and two, regional relapse. Conclusion: The finding of PNI was 5.8%.


laryngeal neoplasms; perineural invasion; prognostic factors; surgery.


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