Archives of Head and Neck Surgery
https://archivesheadnecksurgery.com/article/doi/10.4322/ahns.2018.0028
Archives of Head and Neck Surgery
Original Article Larynx, hypopharynx and tracheal diseases and tumors

Prognostic significance of perineural invasion in laryngeal cancer

Pedro Banho da Rosa, Vítor Martinez de Carvalho, Angelo Sementilli, Leandro Luongo de Matos, Rogério Aparecido Dedivitis

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Abstract

Introduction: Perineural invasion (PNI) may be an independent risk factor for lymph node metastasis in laryngeal cancer, impacting on decreased survival, increased rates of locoregional recurrence, and shortening the period for recurrence. Objective: To evaluate the prognostic significance of PNI in laryngeal cancer. Materials and Methods: This is a retrospective study, with review of anatomopathological material of patients with laryngeal cancer surgically treated from March 2009 to May 2016. The presence of PNI is related to the oncological results. Results: Of the 69 patients studied, four presented PNI in the review of the slides, one of which presented local recurrence and two, regional relapse. Conclusion: The finding of PNI was 5.8%.

Keywords

laryngeal neoplasms; perineural invasion; prognostic factors; surgery.

References

1. Fagan JJ, Collins B, Barnes L, D’Amico F, Myers EM, Johnson JT. Perineural invasion in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 1998;124(6):637-40. http://dx.doi.org/10.1001/archotol.124.6.637. PMid:9639472.

2. Yilmaz T, Hosal AS, Gedikoğlu G, Kaya S. Prognostic significance of histopathological parameters in cancer of the larynx. Eur Arch Otorhinolaryngol. 1999;256(3):139-44. http://dx.doi.org/10.1007/s004050050127. PMid:10234483.

3. Vuralkan E, Akin I, Kuran G, Saka C, Akçayöz N, Alicura S. Prognostic factors in larynx cancers. Kulak Burun Bogaz Ihtis Derg. 2008;18(4):221-6. PMid:19052489.

4. Iovănescu GH, Poenaru M, Doroş C, Borugă O. Histopathological prognostic and risk factors in patients with laryngeal neoplasms. Rom J Morphol Embryol. 2013;54(4):1087-92. PMid:24399006.

5. Liebig C, Ayala G, Wilks JA, Berger DH, Albo D. Perineural invasion in cancer: a review of the literature. Cancer. 2009;115(15):3379-91. http://dx.doi.org/10.1002/cncr.24396. PMid:19484787.

6. Glanz H, Eichhorn T. Prognostic significance of histologic grading in vocal cord carcinoma. HNO. 1985;33(3):103-11. PMid:3997569.

7. Yilmaz T, Sefik Hosal A, Gedikoǧlu G, Önerci M, Gr̈sel B. Prognostic significance of vascular and perineural invasion in cancer of the larynx. Am J Otolaryngol. 1998;19(2):83-8. http://dx.doi.org/10.1016/S0196-0709(98)90100-4. PMid:9550437.

8. Goepfert H, Zaren HA, Jesse RH, Lindberg R. Treatment of laryngeal carcinoma with conservative surgery and postoperative radiation therapy. Arch Otolaryngol. 1978;104(10):576-8. http://dx.doi.org/10.1001/archotol.1978.00790100030006. PMid:697634.

9. Ozdek A, Sarac S, Akyol UM, Unal OF, Sungur A. Histopathological predictors of occult lymph node metástases in supraglottic squamous cell carcinomas. Eur Arch Otorhinolaryngol. 2000;257(7):389-92. http://dx.doi.org/10.1007/s004050000231. PMid:11052252.

10. Morales-Angulo C, Val-Bernal F, Buelta L, Fernandez F, García-Castrillo L, Rama J. Prognostic factors in supraglottic laryngeal carcinoma. Otolaryngol Head Neck Surg. 1998;119(5):548-53. http://dx.doi.org/10.1016/S0194-5998(98)70123-8. PMid:9807091.

11. Gilbert RW, Lundgren JA, Van Nostrand AW, Keane TJ. T3N0M0 glottic carcinoma--a pathologic analysis of 41 patients treated surgically following radiotherapy. Clin Otolaryngol Allied Sci. 1988;13(6):467-79. http://dx.doi.org/10.1111/j.1365-2273.1988.tb00320.x. PMid:3228989.

12. Yousem DM, Gad K, Tufano RP. Resectability issues with head and neck cancer. AJNR Am J Neuroradiol. 2006;27(10):2024-36. PMid:17110661.

13. Chirilă M, Bolboacă SD, Cosgarea M, Tomescu E, Mureşan M. Perineural invasion of the major and minor nerves in laryngeal and hypopharyngeal cancer. Otolaryngol Head Neck Surg. 2009;140(1):65-9. http://dx.doi.org/10.1016/j.otohns.2008.10.019. PMid:19130964.

14. Ambrosio EP, Rosa FE, Domingues MAC, Villacis RAR, Coudry RA, Tagliarini JV, Soares FA, Kowalski LP, Rogatto SR. Cortactin is associated with perineural invasion in the deep invasive front area of laryngeal carcinomas. Hum Pathol. 2011;42(9):1221-9. http://dx.doi.org/10.1016/j.humpath.2010.05.030. PMid:21419472.

15. Bova R, Goh R, Poulson M, Coman WB. Total pharyngolaryngectomy for squamous cell carcinoma of the hypopharynx: a review. Laryngoscope. 2005;115(5):864-9. http://dx.doi.org/10.1097/01.MLG.0000158348.38763.5D. PMid:15867655.

16. Farrag TY, Koch WM, Cummings CW, Goldenberg D, Abou-Jaoude PM, Califano JA, Flint PW, Webster K, Tufano RP. Supracricoid laryngectomy outcomes: the Johns Hopkins experience. Laryngoscope. 2007;117(1):129-32. http://dx.doi.org/10.1097/01.mlg.0000247660.47625.02. PMid:17202941.

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