Archives of Head and Neck Surgery
https://archivesheadnecksurgery.com/article/doi/10.4322/ahns.2018.0881
Archives of Head and Neck Surgery
Original Article Thyroid diseases and tumors

Pediatric thyroid carcinoma: experience in pediatric hospital

João Henrique Cunha Villela, Luiz Roberto Medina dos Santos, Camila Medeiros Machado, Fernanda Cecconello, Vinicius Muraro Bonatto

Downloads: 0
Views: 600

Abstract

Introduction: Thyroid malignancies are not common in the pediatric patients. The objective of this study was to analyze the thyroid cancer patients operated on in a Pediatric Hospital, between 2012 and 2016, with a description of the diagnosis and therapeutics, including a review of the literature. Methods: A retrospective study by reviewing medical records in a Pediatric Hospital, from 1/1/2012 to 12/31/2016. Results: Ten patients diagnosed with thyroid cancer were analyzed in the five years’ period. The female gender was the most affected with 60% of the cases and 70% of the patients undergone total thyroidectomy associated with some kind of neck dissection. The main histological type was papillary carcinoma in 80% of the cases. All patients are alive and well, in a careful follow-up. Conclusion: The results were in accordance to the epidemiological and clinical features observed in the literature, for this pediatric population. It is important a long follow up for these patients.

Keywords

thyroid neoplasms; carcinoma, papillary; pediatrics; thyroid nodule.

References

1. Cardoso AA, Pianovski MAD, França SN, Pereira RM, Boguzewski M, Sandrini R, Hakin Neto CA, Collaço LM, Graf H, Lacerda L Fo Câncer de tireoide na infância e adolescência – relato de 15 casos. Arq Bras Endocrinol Metabol. 2004;48(6):835- 41. http://dx.doi.org/10.1590/S0004-27302004000600009. PMid:15761557.

2. Spinelli C, Bertocchini A, Antonelli A, Miccoli P. Surgical therapy of the thyroid papillary carcinoma in children: experience with 56 patients 16 years old. J Pediatr Surg. 2004;39(10):1500-5. http://dx.doi.org/10.1016/j.jpedsurg.2004.06.016. PMid:15486894.

3. Monte O, Longui CA, Calliari LE, Kochi C, Scalissi NM, Uvo RA, Morone M. Thyroid carcinoma during childhood and adolescence. Endocrinologist. 2005;15(2):106- 10. http://dx.doi.org/10.1097/01.ten.0000157882.36440.1a.

4. Hegedüs L. Clinical practice. The thyroid nodule. N Engl J Med. 2004;351(17):1764-71. http://dx.doi.org/10.1056/NEJMcp031436. PMid:15496625.

5. Buckwalter JA, Gurll NJ, Thomas CG Jr. Cancer of the thyroid in youth. World J Surg. 1981;5(1):15-25. http://dx.doi.org/10.1007/BF01657826. PMid:7233950.

6. Instituto Nacional do Câncer – INCA. Childhood and adolescent cancer in brazil: data from mortality and population- based registries [Internet]. Rio de Janeiro: Instituto Nacional do Câncer; 2009 [cited august 10, 2017]. Available from:  http://www.inca.gov.br

7. Josefson J, Zimmerman D. Thyroid nodules and cancers in children. Pediatr Endocrinol Rev. 2008;6(1):14-23. PMid:18806721.

8. Tomimori EK, Camargo RY, Bisi H, Medeiros-Neto G. Combined ultrasonographic and cytological studies in the diagnosis of thyroid nodules. Biochimie. 1999;81(5):447-52. http://dx.doi.org/10.1016/S0300-9084(99)80094-7. PMid:10403174.

9. Kessler A, Gavriel H, Zahav S, Vaiman M, Shlamkovitch N, Segal S, Eviatar E. Accuracy and consistency of fine-needle aspiration biopsy in the diagnosis and management of solitary thyroid nodules. Isr Med Assoc J. 2005;7(6):371-3. PMid:15984379.

10. Alves C, Silva MSD, Pinto LM, Toralles MBP, Freitas ICF. Aspectos clínicos e diagnósticos de nódulos tireoidianos em crianças e adolescentes. Rev Paul Pediatr. 2006;24:298-302.

11. Vaisman F, Corbo R, Vaisman M, Thyroid Carcinoma in Children and Adolescents—Systematic Review of the Literature. J Thyroid Res. 2011;2011:845362. http://dx.doi.org/10.4061/2011/845362. PMID: 21904689.

12. Hung W, Sarlis NJ. Current controversies in the management of pediatric patients with well-differentiated nonmedullary thyroid cancer: a review. Thyroid. 2002;12(8):683-702. http://dx.doi.org/10.1089/105072502760258668. PMid:12225637.

13. Schlumberger MJ. Papillary and follicular thyroid carcinoma. N Engl J Med. 1998;338(5):297-306. http://dx.doi.org/10.1056/NEJM199801293380506. PMid:9445411.

14. Harness JK, Thompson NW, McLeod MK, Pasieka JL, Fukuuchi A. Differentiated thyroid carcinoma in children and adolescents. World J Surg. 1992;16(4):547-53, discussion 553-4. http://dx.doi.org/10.1007/BF02067317. PMid:1413825.

15. Newman KD, Black T, Heller G, Azizkhan RG, Holcomb GW 3rd, Sklar C, Vlamis V, Haase GM, La Quaglia MP. Differentiated thyroid cancer: determinants of disease progression in patients <21 years of age at diagnosis: a report from the surgical discipline committee of the children’s cancer group. Ann Surg. 1998;227(4):533-41. http://dx.doi.org/10.1097/00000658-199804000-00014. PMid:9563542.

16. Cibas ES, Ali SZ. The bethesda system for reporting thyroid cytopathology. Thyroid. 2009;19(11):1159. http://dx.doi.org/10.1089/thy.2009.0274. PMid:19888858.

17. Katoh R, Sasaki J, Kurihara H, Suzuki K, Iida Y, Kawaoi A. Multiple thyroid involvement (intraglandular metastasis) in papillary thyroid carcinoma. A clinicopathologic study of 105 consecutive patients. Cancer. 1992;70(6):1585-90. http://dx.doi.org/10.1002/1097-0142(19920915)70:6<1585::AID-CNCR2820700623>3.0.CO;2-Z. PMid:1516009.

18. Pasieka JL, Thompson NW, McLeod MK, Burney RE, Macha M, Reeve TS. The incidence of bilateral well differentiated thyroid cancer found at completion thyroidec- tomy. World J Surg. 1992;16(4):711-6, discussion 716-7. http://dx.doi.org/10.1007/BF02067365. PMid:1413840.

19. Tuttle RM, Vaisman F, Tronko MD. Clinical presentation and clinical outcomes in Chernobyl-related paediatric thyroid cancers: what do we know now? What can we expect in the future? Clin Oncol. 2011;23(4):268-75. http://dx.doi.org/10.1016/j.clon.2011.01.178. PMid:21324656.

20. Robie DK, Dinauer CW, Michael Tuttle R, Ward DT, Parry R, McClellan D, Svec R, Adair C, Francis G. The impact of initial surgical management on outcome in young patients with differentiated thyroid cancer. J Pediatr Surg. 1998;33(7):1134-48, discussion 1139-40. http://dx.doi.org/10.1016/S0022-3468(98)90546-2. PMid:9694109.

21. Zimmerman D, Hay ID, Gough IR, Goellner JR, Ryan JJ, Grant CS, McConahey WM. Papillary thyroid carcinoma in children and adults: long-term follow-up of 1039 patients conservatively treated at one institution during three decades. Surgery. 1988;104(6):1157-66. PMid:3194843.

22. Hay ID. Brain metastases from papillary thyroid carcinoma. Arch Intern Med. 1987;147(3):607-11, 611. http://dx.doi.org/10.1001/archinte.1987.00370030205045. PMid:3827442.

23. Bernstein L, Gurney J. Carcinomas and other malignant epithelial neoplasms. In: National Cancer Institute. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995. Bethesda: Cancer Statistics Branch, National Cancer Institute, 1999. p. 139-148.

24. Harach HR, Williams ED. Childhood thyroid cancer in England and Wales. Br J Cancer. 1995;72(3):777-83. http://dx.doi.org/10.1038/bjc.1995.410. PMid:7669594.

25. Hassoun AA, Hay ID, Goellner JR, Zimmerman D. Insular thyroid carcinoma in adolescents: a potentially lethal endocrine malignancy. Cancer. 1997;79(5):1044-8. http://dx.doi.org/10.1002/(SICI)1097-0142(19970301)79:5<1044::AIDCNCR23>3.0.CO;2-0. PMid:9041169.

26. Patel A, Jhiang S, Dogra S, Terrell R, Powers PA, Fenton C, Dinauer CA, Tuttle RM, Francis GL. Differentiated thyroid carcinoma that express sodium-iodide symporter have a lower risk of recurrence for children and adolescents. Pediatr Res. 2002;52(5):737-44. http://dx.doi.org/10.1203/00006450-200211000-00021. PMid:12409522.

27. Faggiano A, Coulot J, Bellon N, Talbot M, Caillou B, Ricard M, Bidart JM, Schlumberger M. Age dependent variation of follicular size and expression of iodine transporters in human thyroid tissue. J Nucl Med. 2004;45(2):232-7. PMid:14960641.

28. Castro MR, Bergert ER, Goellner JR, Hay ID, Morris JC. Immunohistochemical analysis of sodium iodide symporter expression in metastatic differentiated thyroid cancer: correlation with radioiodine uptake. J Clin Endocrinol Metab. 2001;86(11):5627-32. http://dx.doi.org/10.1210/jcem.86.11.8048. PMid:11701745.

29. Min JJ, Chung JK, Lee Y, Jeong JM, Lee DS, Jang JJ, Lee MC, Cho BY. Relationship between expression of the sodium/iodide symporter and 131I uptake in recurrent lesions of differentiated thyroid carcinoma. Eur J Nucl Med. 2001;28(5):639-45. http://dx.doi.org/10.1007/s002590100509. PMid:11383871.

30. Mazzaferri EL, Massoll N. Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin. Endocr Relat Cancer. 2002;9(4):227-47. http://dx.doi.org/10.1677/erc.0.0090227. PMid:12542401.

31. Mazzaferri EL, Kloos RT. Clinical review 128: current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab. 2001;86(4):1447-63. http://dx.doi.org/10.1210/jcem.86.4.7407. PMid:11297567.

32. Maia AL, Ward LS, Carvalho GA, Graf H, Maciel RM, Maciel LM, Rosário PW, Vaisman M. Nódulos de tireoide e câncer diferenciado de tireoide: consenso Brasileiro. Arq Bras Endocrinol Metabol. 2007;51(5):867-93. http://dx.doi.org/10.1590/S0004-27302007000500027. PMid:17891253.

33. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM, American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19(11):1167-214. http://dx.doi.org/10.1089/thy.2009.0110. PMid:19860577.

34. van Santen HM, Aronson DC, Vulsma T, Tummers RF, Geenen MM, de Vijlder JJ, van den Bos C. Frequent adverse events after treatment for childhood onset differentiated thyroid carcinoma: a single institute experience. Eur J Cancer. 2004;40(11):1743-51. http://dx.doi.org/10.1016/j.ejca.2004.03.006. PMid:15251165.

35. Pacini F, Schlumberger M, Dralle H, Elisei R, Smit JW, Wiersinga W, European Thyroid Cancer Taskforce. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol. 2006;154(6):787-803. http://dx.doi.org/10.1530/eje.1.02158. PMid:16728537.

36. Verburg FA, de Keizer B, Lips CJ, Zelissen PM, Klerk JM. Prognostic significance of good response to initial therapy with radioiodine of differentiated thyroid cancer patients. Eur J Endocrinol. 2005;152(1):33-7. http://dx.doi.org/10.1530/eje.1.01819. PMid:15762184.

37. Visman F, Bulzico DA, Pessoa CHCN, Bordallo MAN, Mendonca UBT, Dias FL, Coeli CM, CorboI R, Vaisman M. Prognostic factors of a good response to initial therapy in children and adolescents with differentiated thyroid cancer. Clinics. 2011;66(2):1-6. http://dx.doi.org/10.1590/S1807-59322011000200017.

38. Matuszewska G, Roskosz J, Włoch J, Jurecka-Tuleja B, Hasse-Lazar K, Kowalczyk P, Jarzab B. Evaluation of effects of L-thyroxine therapy in differentiated thyroid carcinoma on the cardiovascular system—prospective study. Wiadomosci Lekarskie. 2001;54(Suppl 1):373-7. PMid:12182052.

39. Mazzaferri EL, Massoll N. Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin. Endocr Relat Cancer. 2002;9(4):227-47. http://dx.doi.org/10.1677/erc.0.0090227. PMid:12542401.

40. Silva KAS, Coelho RC, Agostini AP, Pereira LAF, Dall’Agnol, MM, Dal Lago L. Câncer de tireoide na infância e na adolescência: estudo de casos e revisão da literatura. Revista da AMRIGS. 2010;54(2):169-73.

5af0a1700e8825b108e461c2 archives Articles
Links & Downloads

Arch. Head Neck Surg.

Share this page
Page Sections