Archives of Head and Neck Surgery
Archives of Head and Neck Surgery
Original Article Parathyroid diseases and Tumors

Evolution of renal function in patients with primary hyperparathyroidism submitted to parathyroidectomy

João Henrique Zanotelli dos Santos, Mariana Junqueira Reis Enout, Adriana Terumi Shimozono, Larissa Izumi Fujjiz, Lillian Andrade de Rocha, Rodrigo Oliveira Santos, Murilo Catafesta das Neves

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Introduction: Primary hyperparathyroidism (PHPT) is a hypercalcemic disorder resulting from inappropriate parathyroid secretion (PTH). The surgical treatment is considered the mainstay of therapy. Several studies have observed the worsening of renal function in these patients after parathyroidectomy (PTX), however, the pathophysiology of this phenomenon is unknown. Objective: The purpose of this study is to describe the postoperative renal function in patients with PHPT operated at the Federal University of São Paulo - UNIFESP- between the years 2007 and 2016, evaluating the risk factors for renal function decline. Materials and Methods: This is a cohort study. A total of 142 patients were divided into two groups according to their renal function: Group I (> 60 mL / min / 1.73 m2) and Group II (<60 mL / min / 1.73 m2). Results: Increased serum creatinine was observed in both groups in the first 96 hours, with partial recovery over the first month. Creatinine values> 1.82 mg / dL in patients with renal disease are associated with worse prognosis for renal function after surgery and PTH values> 400 pg / dL are associated with a poor renal outcome, independent of previous renal function. Conclusion: Patients with elevated baseline PTH and creatinine had a worse outcome of renal function one year after surgery


primary hyperparathyroidism; parathyroidectomy; renal insufficiency; postoperative period; glomerular filtration rate.


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