Archives of Head and Neck Surgery
Archives of Head and Neck Surgery
Case Report Tumors of the nose, nasopharynx and paranasal sinuses

Lethal midline granuloma

Caio Paschoalin Trindade; Rogério Aparecido Dedivitis; Silvia Migueis Picado Petrarolha; Kaue Moura; Daniel Partezani

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Lethal midline granuloma is a syndrome with ulcerative vegetative lesion destructing nose, paranasal sinus and palate. Nasal type T-NK cells Lymphoma is often related with this syndrome and without treatment the mortality tax is around 100%. There is association with systemic infection with Epstein Barr Virus. The treatment is the association of radiotherapy and chemotherapy. A 70-year-old male patient presented nose congestion and bleeding with fast growing of an ulcerative lesion in the nose. The computer tomography showed destruction of nose septum and right sinuses. The biopsy diagnosis was nasal type T-NK cells lymphoma.


granuloma; lethal midline; lymphoma; T-Cell; nose neoplasms.


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