Archives of Head and Neck Surgery
Archives of Head and Neck Surgery
Case Report Lip and oral cavity tumors

Spontaneous regression of oral mucosal malignant melanoma

Andressa Almeida de Oliveira, Lee I-Ching, Gilberto Vaz Teixeira

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Oral mucosal Malignant Melanoma (MM) is a rare manifestation of melanomas, and Spontaneous Regression (SR) of this tumor is reported mainly for cutaneous lesions. A 52-year-old man with a lesion on the hard palate, where biopsy showed malignant melanoma in situ. Patient refused treatment, but a near total clinical remission of the lesion was observed and documented. The pathological analysis of the surgical excision of this lesion, showed no malignancy. This case showed the clinical and anatomopathological documentations suggesting the potential influencing of inflammatory and immunological reactions leading to a regression of the primary tumor.


melanoma; neoplasm regression, spontaneous; immunity, mucosal; palate, hard.


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