Laryngeal neuroendocrine tumor
Ágatha Rossi Dias, Angela dos Anjos Couto, Daniel Herman Partezani, Rogério Aparecido Dedivitis, André Vicente Guimarães
Generally rare, neuroendocrine tumors of the larynx are more frequent in the supraglottic region. They predominate in males and develop around 50 years of age. They are divided into typical carcinoid, atypical carcinoid, small cell neuroendocrine tumors and paraganglioma. A 52-year-old male patient, former smoker, complained of a foreign body sensation in his throat for three years, in addition to local pain. A laryngoscopy revealed a polypoid lesion in the right arytenoid. The diagnostic approach adopted was laryngeal microsurgery for excisional biopsy, and the anatomopathological analysis showed an atypical carcinoid. The patient underwent adjuvant chemotherapy; evidence of recurrence was not found after five years.
1. Goldman NC, Hood C, Singleton GT. Carcinoid of the larynx. Arch Otolaryngol. 1969;90(1):64-7. PMid:5785991.
2. Devaney KO, Ferlito A, Rinaldo A. Neuroendocrine carcinomas of the larynx: What do the different histologic types really mean. Eur Arch Otorhinolaryngol. 2010;267(9):1323-5. http://dx.doi.org/10.1007/s00405-010-1318-8. PMid:20589504.
3. Lewis JS Jr, Ferlito A, Gnepp DR, Rinaldo A, Devaney KO, Silver CE, Travis WD. Terminology and classification of neuroendocrine neoplasms of the larynx. Laryngoscope. 2011;121(6):1187-93. http://dx.doi.org/10.1002/lary.21790. PMid:21557244.
4. Schüffner ROA, Santos HB, Barbosa LAO, Chaves ALF, Muniz LV, Ribeiro RIMA, Soares JMA. Carcinoma neuroendócrinio de pequenas células de laringe: relato de caso e revisão da literatura. Rev Assoc Catarinense Med. 2012;41:85-8.
5. Moisa II, Silver CE. Treatment of neuroendocrine neoplasms of the larynx. ORL J Otorhinolaryngol Relat Spec. 1991;53(4):259-64. http://dx.doi. org/10.1159/000276225. PMid:1653932.