Archives of Head and Neck Surgery
Archives of Head and Neck Surgery
Case Report tumor and non tumoral diseases of salivary glands

Parotid matastasis of clear-cell renal cell carcinoma (ccRCC): a case report

Mariana Brito Martire, Luís Flávio Villena, Jairo Alves de Sousa Junior, José Raphael Moura Campos Montoro, Silvio Antônio Bertacchi Uvo

Downloads: 0
Views: 245


Introduction: Malignant neoplasm of the mouth is a very common disease, being the sixth most common cancer location worldwide. Objective: This study was conducted with the aim of evaluating the applicability and the relationship between cell damage intensity and Oral cavity squamous cell carcinoma (OCSCC) clinical stages. Methods: A total of 44 individuals, 24 oral cancer patients and 20 healthy volunteers participated in this study. The exfoliated cells from the oral cavity were collected using a wooden spatula. All samples were analyzed by comet assay, micronucleus assay and cell death assay. Results: Our results indicate that the diagnosis of OCSCC increases the frequency of genotoxic damage (comet assay – 3.21x; micronucleus assay – 3.93x). However, it was not possible to establish a correlation between frequency of DNA damage and disease staging. The cell death assay was not effective for the proposed biomonitoring. Given these findings, we consider the comet and micronucleus assays to be adequate for biomonitoring DNA damage. Conclusion: With the current design, we could not demonstrate the applicability of these assays to correlate the intensity of DNA/cell damage and the clinical stages of OCSCC. Nevertheless, further studies need to be performed to enhance sample size and increase the statistical power of our findings


cancer; parotid; metastasis; otorhinolaryngology; kidney.


1. Bron LP, Traynor SJ, McNeil EB, O’Brien CJ. Primary and metastatic cancer of the parotid: comparison of clinical behavior in 232 cases. Laryngoscope. 2003;113(6):1070-5. PMid:12782825.

2. Spreafico R, Nicoletti G, Ferrario F, Scanziani R, Grasso M. Parotid metastasis from renal cell carcinoma: a case report and review of the literature. Acta Otorhinolaryngol Ital. 2008;28(5):266-8. PMid:19186459.

3. Park YW, Hlivko TJ. Parotid gland metastasis from renal cell carcinoma. Laryngoscope. 2002;112(3):453-6. PMid:12148853.

4. Gnepp DR. Diagnostic surgical pathology of the head and neck. 2nd ed. Philadelphia: Elsevier Saunders; 2009. 1205 p.

5. Udager AM, Rungta SA. Metastatic renal cell carcinoma, clear cell type, of the parotid gland: a case report, review of literature, and proposed algorithmic approach to salivary gland clear cell neoplasms in fine-needle aspiration biopsies. Diagn Cytopathol. 2014;42(11):974-83. PMid:24535952.

6. Tsai SC, Hsu H. Parotid neoplasms: diagnosis, treatment, and intraparotid facial nerve anatomy. J Laryngol Otol. 2002;116(5):359-62. PMid:12080993.

7. Lopez-Beltran A, Scarpelli M, Montironi R, Kirkali Z. 2004 WHO classification of renal tumours of the adults. Eur Urol. 2006;49(5):798-805. PMid:16442207.

8. Lawlor CM, Wein RO. Parotid metastasis of renal cell carcinoma: a case report and review of the literature. J Cancer Ther Res. 2012;1(1):1-15.

9. Campbell SC, Lane BR. Malignant renal tumors. In: Wein AJ, editors. CampbellWalsh urology. 10th ed. Philadelphia, PA: Saunders/Elsevier; 2007. p. 1413-74

Submitted date:

Accepted date:

614dcf33a95395144d3300e2 archives Articles
Links & Downloads

Arch. Head Neck Surg.

Share this page
Page Sections